Thomas, S. and Makris, M. orcid.org/0000-0001-7622-7939 (2018) The reversal of anticoagulation in clinical practice. Clinical Medicine, 18 (4). pp. 314-319. ISSN 1470-2118
Abstract
Widespread use of anticoagulant drugs for treatment and prevention of thromboembolic events means it is common to encounter patients requiring reversal of anticoagulation for management of bleeding or invasive procedures. While supportive and general measures apply for patients on all agents, recent diversification in the number of licensed agents makes an understanding of drug-specific reversal strategies essential. Recognising effects upon, and limitations of, laboratory measures of coagulation also plays an important role. An understanding of reversal strategies alone is insufficient to competently care for patients who may require anticoagulation reversal. It is also necessary to reduce the need for reversal through correct prescribing and by employing appropriate periprocedural bridging strategies for elective and semi-elective procedures. Finally, consideration of whether and when to reintroduce an anticoagulant drug following reversal is important not only to balance bleeding and thrombotic risks for individual patients but also for timely management of discharge.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © Royal College of Physicians 2018. Reproduced in accordance with the publisher's self-archiving policy. |
Keywords: | Anticoagulants; direct acting oral anticoagulants; reversal; haemorrhage; surgery |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 06 Sep 2018 10:59 |
Last Modified: | 01 Aug 2019 00:42 |
Published Version: | https://doi.org/10.7861/clinmedicine.18-4-314 |
Status: | Published |
Publisher: | Royal College of Physicians |
Refereed: | Yes |
Identification Number: | 10.7861/clinmedicine.18-4-314 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:135344 |