Guo, Li, Winzer, Thilo Hans orcid.org/0000-0003-0423-9986, Yang, Xiaofei et al. (8 more authors) (2018) The opium poppy genome and morphinan production. Science. pp. 343-347. ISSN 0036-8075
Abstract
Morphinan-based painkillers are derived from opium poppy (Papaver somniferum L.). We report a draft of the opium poppy genome, with 2.72 gigabases assembled into 11 chromosomes with contig N50 and scaffold N50 of 1.77 and 204 megabases, respectively. Synteny analysis suggests a whole-genome duplication at ∼7.8 million years ago and ancient segmental or whole-genome duplication(s) that occurred before the Papaveraceae-Ranunculaceae divergence 110 million years ago. Syntenic blocks representative of phthalideisoquinoline and morphinan components of a benzylisoquinoline alkaloid cluster of 15 genes provide insight into how this cluster evolved. Paralog analysis identified P450 and oxidoreductase genes that combined to form the STORR gene fusion essential for morphinan biosynthesis in opium poppy. Thus, gene duplication, rearrangement, and fusion events have led to evolution of specialized metabolic products in opium poppy.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Dates: |
|
Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) > Centre for Novel Agricultural Products (CNAP) (York) The University of York > Faculty of Sciences (York) > Biology (York) |
Funding Information: | Funder Grant number BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL) BB/K018809/1 |
Depositing User: | Pure (York) |
Date Deposited: | 03 Sep 2018 16:20 |
Last Modified: | 21 Jan 2025 17:35 |
Published Version: | https://doi.org/10.1126/science.aat4096 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1126/science.aat4096 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:135262 |
Download
Filename: aat4096_ArticleContent_plus_figures.pdf
Description: aat4096_ArticleContent_plus_figures