Dupont, D, Alric, M, Blanquet-Diot, S et al. (14 more authors) (2019) Can dynamic in vitro digestion systems mimic the physiological reality? Critical Reviews in Food Science and Nutrition, 59 (10). pp. 1546-1562. ISSN 1040-8398
Abstract
During the last decade, there has been a growing interest in understanding the fate of food during digestion in the gastrointestinal tract in order to strengthen the possible effects of food on human health. Ideally, food digestion should be studied in vivo on humans but this is not always ethically and financially possible. Therefore simple static in vitro digestion models mimicking the gastrointestinal tract have been proposed as alternatives to in vivo experiments but these models are quite basic and hardly recreate the complexity of the digestive tract. In contrast, dynamic models that allow pH regulation, flow of the food and injection in real time of digestive enzymes in the different compartments of the gastrointestinal tract are more promising to accurately mimic the digestive process. Most of the systems developed so far have been compared for their performances to in vivo data obtained on animals and/or humans. The objective of this article is to review the validation towards in vivo data of some of the dynamic digestion systems currently available in order to determine what aspects of food digestion they are able to mimic. Eight dynamic digestion systems are presented as well as their validation towards in vivo data. Advantages and limits of each simulator is discussed. This is the result of a cooperative international effort made by some of the scientists involved in Infogest, an international network on food digestion.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Taylor & Francis Group, LLC. This is an author produced version of a paper published in Critical Reviews in Food Science and Nutrition. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Dynamic in vitro digestion; food; stomach; small intestine; colon |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 04 Sep 2018 14:40 |
Last Modified: | 04 Jun 2019 13:12 |
Status: | Published |
Publisher: | Taylor and Francis |
Identification Number: | 10.1080/10408398.2017.1421900 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:135229 |