Mücke, T, Wolff, C, Fichter, AM et al. (3 more authors) (2018) Detection of thrombosis in microvessels with indocyanine green videoangiography. British Journal of Oral and Maxillofacial Surgery, 56 (8). pp. 678-683. ISSN 0266-4356
Abstract
Atherosclerosis is a systemic condition that is responsible for many diseases, and becomes a problem in cases where plaques form at several sites. The formation of a thrombotic embolus may jeopardise vascular operations, including microvascular anastomoses in replantation procedures or free tissue transfers. A mobile imaging tool for the detection of thrombosis preoperatively or intraoperatively would be valuable. An intimal injury, simulating removal of atherosclerotic plaques, was made microsurgically in 60 rat aortas, and results were analysed macroscopically, histologically, and with intraoperative indocyanine green (ICG) videoangiography immediately postoperatively. The Spearman and Pearson correlation tests were used to compare the three techniques. The sensitivity and specificity of ICG videoangiography was calculated in relation to both macroscopic and histological results. Detection of thrombosis was possible in 25 cases, and in 18 cases no thrombosis was correctly diagnosed by all methods used. In 31 of 60 specimens formation of thrombus was detected histologically, and in 29 of 60 examinations it was detected clinically, which yielded a correlation of 93.5% between the two examinations. Macroscopic analysis correlated better with ICG videoangiography (sensitivity 86.2% and specificity 64.5%) than histological observations (sensitivity 80.6% and specificity 62.1%). There was a significant correlation among all comparisons (each p ≤ 0.001) with correlation indexes of 0.94, 0.52, and 0.44 for macroscopic/histological, clinical/ICG videoangiographic, and ICG videoangiographic/histological results, respectively. Our results show that ICG videoangiography is an important method for the detection of formation of acute thrombi and may be an important tool in vascular procedures.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. This is an author produced version of a paper published in British Journal of Oral and Maxillofacial Surgery. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Indocyanine green videoangiography; prediction of thrombi; endothelial defects |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > School of Dentistry Visitors (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 04 Sep 2018 10:30 |
Last Modified: | 30 Jul 2019 00:39 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.bjoms.2018.07.005 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:135227 |
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