Pautrat, A., Rolland, M., Barthelemy, M. et al. (7 more authors) (2018) Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing. eLife, 7. e36607. ISSN 2050-084X
Abstract
Pain is a prevalent symptom of Parkinson's disease, and is effectively treated by deep brain stimulation of the subthalamic nucleus (STN). However, the link between pain and the STN remains unclear. In the present work, we report that STN neurons exhibit complex tonic and phasic responses to noxious stimuli using in vivo electrophysiology in rats. We also show that nociception is altered following lesions of the STN, and characterize the role of the superior colliculus and the parabrachial nucleus in the transmission of nociceptive information to the STN, physiologically from both structures and anatomically in the case of the parabrachial nucleus. We show that STN nociceptive responses are abnormal in a rat model of PD, suggesting their dependence on the integrity of the nigrostriatal dopaminergic system. The STN-linked nociceptive network we reveal is likely to be of considerable clinical importance in neurological diseases involving a dysfunction of the basal ganglia.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2018 Pautrat et al. This article is distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use and redistribution provided that the original author and source are credited. |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 30 Aug 2018 08:54 |
Last Modified: | 19 Oct 2021 15:36 |
Status: | Published |
Publisher: | eLife Sciences Publications Ltd |
Refereed: | Yes |
Identification Number: | 10.7554/eLife.36607 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:135076 |