Mozumder, M, Beltrachini, L, Collier, Q et al. (2 more authors) (2018) Simultaneous magnetic resonance diffusion and pseudo-diffusion tensor imaging. Magnetic Resonance in Medicine, 79 (4). pp. 2367-2378. ISSN 0740-3194
Abstract
Purpose
An emerging topic in diffusion magnetic resonance is imaging blood microcirculation alongside water diffusion using the intravoxel incoherent motion (IVIM) model. Recently, a combined IVIM diffusion tensor imaging (IVIM‐DTI) model was proposed, which accounts for both anisotropic pseudo‐diffusion due to blood microcirculation and anisotropic diffusion due to tissue microstructures. In this article, we propose a robust IVIM‐DTI approach for simultaneous diffusion and pseudo‐diffusion tensor imaging.
Methods
Conventional IVIM estimation methods can be broadly divided into two‐step (diffusion and pseudo‐diffusion estimated separately) and one‐step (diffusion and pseudo‐diffusion estimated simultaneously) methods. Here, both methods were applied on the IVIM‐DTI model. An improved one‐step method based on damped Gauss–Newton algorithm and a Gaussian prior for the model parameters was also introduced. The sensitivities of these methods to different parameter initializations were tested with realistic in silico simulations and experimental in vivo data.
Results
The one‐step damped Gauss–Newton method with a Gaussian prior was less sensitive to noise and the choice of initial parameters and delivered more accurate estimates of IVIM‐DTI parameters compared to the other methods.
Conclusion
One‐step estimation using damped Gauss–Newton and a Gaussian prior is a robust method for simultaneous diffusion and pseudo‐diffusion tensor imaging using IVIM‐DTI model.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2017, The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License [https://creativecommons.org/licenses/by/4.0/], which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Magnetic resonance imaging; diffusion; perfusion; intravoxel incoherent motion |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Computing (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 30 Aug 2018 11:37 |
Last Modified: | 30 Aug 2018 13:16 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/mrm.26840 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:135008 |
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