Borodavka, A orcid.org/0000-0002-5729-2687, Desselberger, U and Patton, JT (2018) Genome packaging in multi-segmented dsRNA viruses: distinct mechanisms with similar outcomes. Current Opinion in Virology, 33. pp. 106-112. ISSN 1879-6257
Abstract
Segmented double-stranded (ds)RNA viruses share remarkable similarities in their replication strategy and capsid structure. During virus replication, positive-sense single-stranded (+)RNAs are packaged into procapsids, where they serve as templates for dsRNA synthesis, forming progeny particles containing a complete equimolar set of genome segments. How the +RNAs are recognized and stoichiometrically packaged remains uncertain. Whereas bacteriophages of the Cystoviridae family rely on specific RNA–protein interactions to select appropriate +RNAs for packaging, viruses of the Reoviridae instead rely on specific inter-molecular interactions between +RNAs that guide multi-segmented genome assembly. While these families use distinct mechanisms to direct +RNA packaging, both yield progeny particles with a complete set of genomic dsRNAs.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) > Bioinformatics (Leeds) |
Funding Information: | Funder Grant number Wellcome Trust 103068/Z/13/Z |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Aug 2018 09:00 |
Last Modified: | 24 Aug 2018 13:52 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.coviro.2018.08.001 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:134961 |