Twarock, R, Bingham, RJ, Dykeman, EC et al. (1 more author) (2018) A modelling paradigm for RNA virus assembly. Current Opinion in Virology, 31. pp. 74-81. ISSN 1879-6257
Abstract
Virus assembly, a key stage in any viral life cycle, had long been considered to be primarily driven by protein–protein interactions and nonspecific interactions between genomic RNA and capsid protein. We review here a modelling paradigm for RNA virus assembly that illustrates the crucial roles of multiple dispersed, specific interactions between viral genomes and coat proteins in capsid assembly. The model reveals how multiple sequence-structure motifs in the genomic RNA, termed packaging signals, with a shared coat protein recognition motif enable viruses to overcome a viral assembly-equivalent of Levinthal’s Paradox in protein folding. The fitness advantages conferred by this mechanism suggest that it should be widespread in viruses, opening up new perspectives on viral evolution and anti-viral therapy.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018, The Authors. Published by Elsevier B.V. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) > Biological Chemistry (Leeds) |
Funding Information: | Funder Grant number Wellcome Trust 110145/Z/15/Z |
Depositing User: | Symplectic Publications |
Date Deposited: | 23 Aug 2018 10:56 |
Last Modified: | 25 Jun 2023 21:29 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.coviro.2018.07.003 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:134911 |