Rello, J, van Engelen, TSR, Alp, E et al. (9 more authors) (2018) Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases. Clinical Microbiology and Infection, 24 (12). pp. 1264-1272. ISSN 1198-743X
Abstract
Background
Our current understanding of the pathophysiology and management of sepsis is associated with a lack of progress in clinical trials, which partly reflects insufficient appreciation of the heterogeneity of this syndrome. Consequently, more patient-specific approaches to treatment should be explored.
Aims
To summarize the current evidence on precision medicine in sepsis, with an emphasis on translation from theory to clinical practice. A secondary objective is to develop a framework enclosing recommendations on management and priorities for further research.
Sources
A global search strategy was performed in the MEDLINE database through the PubMed search engine (last search December 2017). No restrictions of study design, time, or language were imposed.
Content
The focus of this Position Paper is on the interplay between therapies, pathogens, and the host. Regarding the pathogen, microbiologic diagnostic approaches (such as blood cultures (BCs) and rapid diagnostic tests (RDTs)) are discussed, as well as targeted antibiotic treatment. Other topics include the disruption of host immune system and the use of biomarkers in sepsis management, patient stratification, and future clinical trial design. Lastly, personalized antibiotic treatment and stewardship are addressed (Fig. 1).
Implications
A road map provides recommendations and future perspectives. RDTs and identifying drug-response phenotypes are clear challenges. The next step will be the implementation of precision medicine to sepsis management, based on theranostic methodology. This highly individualized approach will be essential for the design of novel clinical trials and improvement of care pathways.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Big data; Biomarkers; Host defence; Low- and middle-income countries; Microbiome; Personalized medicine; Precision medicine; Rapid diagnostic test (RDT); Theranostics; Treatment |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Molecular Gastroenterology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 23 Aug 2018 14:23 |
Last Modified: | 13 Dec 2018 10:18 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.cmi.2018.03.011 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:134888 |