Fulton, B, Short, SC orcid.org/0000-0003-4423-7256, James, A et al. (8 more authors) (2018) PARADIGM-2: Two parallel phase I studies of olaparib and radiotherapy or olaparib and radiotherapy plus temozolomide in patients with newly diagnosed glioblastoma, with treatment stratified by MGMT status. Clinical and Translational Radiation Oncology, 8. pp. 12-16. ISSN 2405-6308
Abstract
Glioblastoma has a dismal prognosis and molecular targeted agents have failed to improve outcomes to date. PARADIGM-2 is a phase I dose escalation study evaluating olaparib plus radiotherapy ± temozolomide in newly diagnosed glioblastoma, using MGMT methylation status to stratify patients and inform treatment schedules.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2017 The Authors. Published by Elsevier Ireland Ltd on behalf of European Society for Radiotherapy and Oncology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | Glioblastoma; Poly(ADP-ribose) polymerase; Olaparib; Radiotherapy; O6-methylguanine methyltransferase; Dose escalation; Radiosensitizer |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 15 Aug 2018 11:21 |
Last Modified: | 15 Aug 2018 11:21 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.ctro.2017.11.003 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:134617 |