Vergara, C, Lange, M, Palamara, S et al. (3 more authors) (2016) A coupled 3D–1D numerical monodomain solver for cardiac electrical activation in the myocardium with detailed Purkinje network. Journal of Computational Physics, 308. pp. 218-238. ISSN 0021-9991
Abstract
We present a model for the electrophysiology in the heart to handle the electrical propagation through the Purkinje system and in the myocardium, with two-way coupling at the Purkinje–muscle junctions. In both the subproblems the monodomain model is considered, whereas at the junctions a resistor element is included that induces an orthodromic propagation delay from the Purkinje network towards the heart muscle. We prove a sufficient condition for convergence of a fixed-point iterative algorithm to the numerical solution of the coupled problem. Numerical comparison of activation patterns is made with two different combinations of models for the coupled Purkinje network/myocardium system, the eikonal/eikonal and the monodomain/monodomain models. Test cases are investigated for both physiological and pathological activation of a model left ventricle. Finally, we prove the reliability of the monodomain/monodomain coupling on a realistic scenario. Our results underlie the importance of using physiologically realistic Purkinje-trees with propagation solved using the monodomain model for simulating cardiac activation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015 Elsevier Inc. This is an author produced version of a paper published in Journal of Computational Physics. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Computational electrocardiology; Purkinje fibers; Monodomain equation; Pull and push effect |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Computing (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 15 Aug 2018 14:07 |
Last Modified: | 15 Aug 2018 14:07 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.jcp.2015.12.016 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:134530 |