Pradhan, S.U., Sen, M., Li, J. et al. (4 more authors) (2018) Characteristics of Multi-Component Formulation Granules Formed using Distributive Mixing Elements in Twin Screw Granulation. Drug Development and Industrial Pharmacy, 44 (11). pp. 1826-1837. ISSN 0363-9045
Abstract
This work examines the influence of pharmaceutical powder formulation characteristics on granule properties formed using distributive mixing elements (DMEs) in twin screw granulation. High and low drug dose formulations with three different active pharmaceutical ingredients (APIs) were considered. The type and concentration of the API in the formulation significantly affected the dry blend particle size distribution and the wet blend dynamic yield strength. However, despite the differences in blend properties, the granule size distributions were not significantly affected by the type of API used. The granule size distributions were solely functions of the liquid-to-solid ratio and the screw element geometry. However, the granule porosities were observed to be dependent on both the liquid-to-solid ratio and the dynamic yield strength of the blends. This work is the first to study the influence of drug loading and API type on the granule attributes produced using distributive mixing elements.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This is an Accepted Manuscript of an article published by Taylor & Francis in Drug Development and Industrial Pharmacy on 20 Jul 2018, available online: https://doi.org/10.1080/03639045.2018.1503293 |
Keywords: | Distributive mixing elements; formulation properties; granule breakage; granule properties; twin screw granulation |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Chemical and Biological Engineering (Sheffield) |
Funding Information: | Funder Grant number CENTRE FOR PROCESS INNOVATION UNSPECIFIED |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 10 Aug 2018 14:36 |
Last Modified: | 26 Aug 2020 06:52 |
Status: | Published |
Publisher: | Taylor & Francis |
Refereed: | Yes |
Identification Number: | 10.1080/03639045.2018.1503293 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:134434 |