White, H, Shaw, N, Denman, S et al. (3 more authors) (2017) Variation in lung function as a marker of adherence to oral and inhaled medication in cystic fibrosis. European Respiratory Journal, 49 (3). ARTN 1600987. ISSN 0903-1936
Abstract
The adherence of patients aged ≥16 years from an adult CF centre was measured by medication possession ratio (MPR) and self-report. Patients were assigned to one of three adherence categories (<50%, 50 to <80%, ≥80%) by their composite score (MPR). Ordinal regression was used to identify predictors of adherence, including coefficient variation measures for forced expiratory volume in 1 s (FEV₁), weight and C-reactive protein concentration, measured from 6 months and 12 months before baseline.
MPR data for 106 of 249 patients (mean age 29.8±9.2 years) was retrieved, indicating a mean adherence of 63%. The coefficient of variation for FEV₁ was inversely related to adherence and was a univariate predictor of adherence (6 months: OR 0.92, 95% CI 0.87–0.98, p=0.005; 12 months: OR 0.94, 95% CI 0.93–0.99, p=0.03) and remained significant in the final models. The coefficient of variation of weight and C-reactive protein were not predictive of adherence.
The coefficient of variation of FEV₁ was identified as an objective predictor of adherence. Further evaluation of this potential marker of adherence is now required.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | ©ERS 2017. This is an author produced version of a paper published in European Respiratory Journal. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Translational Medicine (Leeds) |
Funding Information: | Funder Grant number Gilead Sciences Ltd PO 303260 |
Depositing User: | Symplectic Publications |
Date Deposited: | 03 Aug 2018 10:32 |
Last Modified: | 23 May 2019 14:46 |
Status: | Published |
Publisher: | European Respiratory Society |
Identification Number: | 10.1183/13993003.00987-2016 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:134097 |