Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium

Abstract

Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.

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Item Type:	Article
Authors/Creators:	Bryant, JM Grogono, DM Rodriguez-Rincon, D Everall, I Brown, KP Moreno, P Verma, D Hill, E Drijkoningen, J Gilligan, P Esther, CR Noone, PG Giddings, O Bell, SC Thomson, R Wainwright, CE Coulter, C Pandey, S Wood, ME Stockwell, RE Ramsay, KA Sherrard, LJ Kidd, TJ Jabbour, N Johnson, GR Knibbs, LD Morawska, L Sly, PD Jones, A Bilton, D Laurenson, I Ruddy, M Bourke, S Bowler, ICJW Chapman, SJ Clayton, A Cullen, M Dempsey, O Denton, M Desai, M Drew, RJ Edenborough, F Evans, J Folb, J Daniels, T Humphrey, H Isalska, B Jensen-Fangel, S Jönsson, B Jones, AM Katzenstein, TL Lillebaek, T MacGregor, G Mayell, S Millar, M Modha, D Nash, EF O'Brien, C O'Brien, D Ohri, C Pao, CS Peckham, D https://orcid.org/0000-0001-7723-1868 Perrin, F Perry, A Pressler, T Prtak, L Qvist, T Robb, A Rodgers, H Schaffer, K Shafi, N Van Ingen, J Walshaw, M Watson, D West, N Whitehouse, J Haworth, CS Harris, SR Ordway, D Parkhill, J Andres Floto, R
Copyright, Publisher and Additional Information:	© 2016, American Association for the Advancement of Science. This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 11 Nov 2016, Volume 354, DOI: 10.1126/science.aaf8156.
Dates:	Published: 11 November 2016 Accepted: 23 September 2016
Institution:	The University of Leeds
Depositing User:	Symplectic Publications
Date Deposited:	03 Aug 2018 12:24
Last Modified:	08 Nov 2019 06:02
Status:	Published
Publisher:	American Association for the Advancement of Science
Identification Number:	10.1126/science.aaf8156
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:134090

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Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium

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