Griggs, Samuel D., Tape, Daniel T. and Clarke, Paul A. orcid.org/0000-0003-3952-359X (2018) Strategies for the Synthesis of Spiropiperidines - A Review of the Last 10 Years. Organic and Biomolecular Chemistry. pp. 6620-6633. ISSN 1477-0539
Abstract
Spiropiperidines have gained in popularity in drug discovery programmes as medicinal chemists explore new areas of three-dimensional chemical space. This review focuses on the methodology used for the construction of 2-, 3- and 4- spiropiperidines, covering the literature from the last 10 years. It classifies the synthesis of each of the types of spiropiperidine by synthetic strategy: the formation of the spiro-ring on a preformed piperidine ring, and the formation of the piperidine ring on a preformed carbo- or heterocyclic ring. While 3- and 4-spiropiperidines are predominantly synthesised for drug discovery projects, 2-spiropiperidines are synthesised en route to natural products. The lack of 2- spiropiperidines in drug discovery is presumably due to limited general procedures for their synthesis.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018, The Royal Society of Chemistry.This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Keywords: | Spirocycles,Piperidines,Medicinal chemistry |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 24 Jul 2018 23:53 |
Last Modified: | 08 Feb 2025 00:30 |
Published Version: | https://doi.org/10.1039/C8OB01271G |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1039/C8OB01271G |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:133813 |
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