Guiselin, B., Law, J.O., Chakrabarti, B. et al. (1 more author) (2018) Dynamic Morphologies and Stability of Droplet Interface Bilayers. Physical Review Letters, 120 (23). 238001. ISSN 0031-9007
Abstract
We develop a theoretical framework for understanding dynamic morphologies and stability of droplet interface bilayers (DIBs), accounting for lipid kinetics in the monolayers and bilayer, and droplet evaporation due to imbalance between osmotic and Laplace pressures. Our theory quantitatively describes distinct pathways observed in experiments when DIBs become unstable. We find that when the timescale for lipid desorption is slow compared to droplet evaporation, the lipid bilayer will grow and the droplets approach a hemispherical shape. In contrast, when lipid desorption is fast, the bilayer area will shrink and the droplets eventually detach. Our model also suggests there is a critical size below which DIBs can become unstable, which may explain experimental difficulties in miniaturizing the DIB platform.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Physics and Astronomy (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 09 Aug 2018 14:53 |
Last Modified: | 06 Nov 2018 13:51 |
Published Version: | https://doi.org/10.1103/PhysRevLett.120.238001 |
Status: | Published |
Publisher: | American Physical Society |
Refereed: | Yes |
Identification Number: | 10.1103/PhysRevLett.120.238001 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:133640 |