Scally, B, Burke, MR orcid.org/0000-0002-2561-053X, Bunce, D orcid.org/0000-0003-3265-2700 et al. (1 more author) (2018) Resting state EEG power and connectivity are associated with alpha peak frequency slowing in healthy aging. Neurobiology of Aging, 71. pp. 149-155. ISSN 0197-4580
Abstract
The individual alpha peak frequency (IAPF) of the human EEG typically experiences slowing with increasing age. Despite this hallmark change, studies that investigate modulations of conventional EEG alpha power and connectivity by aging and age-related neuropathology neglect to account for inter-group differences in IAPF. To investigate the relationship of age-related IAPF slowing with EEG power and connectivity, we recorded eyes-closed resting state EEG in 37 young adults and 32 older adults. We replicated the finding of a slowed IAPF in older adults. IAPF values were significantly correlated with the frequency of maximum global connectivity and the means of their distributions did not differ, suggesting that connectivity was highest at the IAPF. Older adults expressed reduced global EEG power and connectivity at the conventional upper alpha band (10-12 Hz) compared to young adults. In contrast, groups had equivalent power and connectivity at the IAPF. The results suggest that conventional spectral boundaries may be biased against older adults or any group with a slowed IAPF. We conclude that investigations of alpha activity in aging and age-related neuropathology should be adapted to the IAPF of the individual and that previous findings should be interpreted with caution. EEG in the dominant alpha range may be unsuitable for examining cortico-cortical connectivity due to its subcortical origins.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Published by Elsevier Inc. This is an author produced version of a paper published in Neurobiology of Aging. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Psychology (Leeds) |
Funding Information: | Funder Grant number Alzheimer's Research UK ARUK-PPG2014A-19 |
Depositing User: | Symplectic Publications |
Date Deposited: | 19 Jul 2018 15:00 |
Last Modified: | 17 Jul 2019 00:39 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.neurobiolaging.2018.07.004 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:133472 |