Stephens, Thomas C, Lawer, Aggie, French, Thomas et al. (1 more author) (2018) Iterative Assembly of Macrocyclic Lactones using Successive Ring Expansion Reactions. Chemistry : A European Journal. pp. 13947-13953. ISSN 1521-3765
Abstract
Macrocyclic lactones can be prepared from lactams and hydroxyacid derivatives via an efficient 3- or 4-atom iterative ring expansion protocol. The products can also be expanded using amino acid-based linear fragments, meaning that macrocycles with precise sequences of hydroxy- and amino acids can be assembled in high yields by 'growing' them from smaller rings, using a simple procedure in which high dilution is not required. The method should significantly expedite the practical synthesis of diverse nitrogen containing macrolide frameworks.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2018 The Authors. |
Keywords: | Journal Article |
Dates: |
|
Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number EPSRC EP/P029795/1 |
Depositing User: | Pure (York) |
Date Deposited: | 18 Jul 2018 08:40 |
Last Modified: | 21 Jan 2025 17:34 |
Published Version: | https://doi.org/10.1002/chem.201803064 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/chem.201803064 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:133462 |
Download
Filename: Stephens_et_al_2018_Chemistry_A_European_Journal.pdf
Description: Stephens_et_al-2018-Chemistry_-_A_European_Journal
Licence: CC-BY 2.5