Rode, B, Bailey, MA orcid.org/0000-0001-5038-1970, Marthan, R et al. (2 more authors) (2018) ORAI Channels as Potential Therapeutic Targets in Pulmonary Hypertension. Physiology, 33 (4). pp. 261-268. ISSN 1548-9213
Abstract
Pulmonary hypertension is a complex and fatal disease that lacks treatments. Its pathophysiology involves pulmonary artery hyperreactivity, endothelial dysfunction, wall remodelling, inflammation, and thrombosis, which could all depend on ORAI Ca2+ channels. We review the knowledge about ORAI channels in pulmonary artery and discuss the interest to target them in the treatment of pulmonary hypertension.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 American Physiological Society. This is an author produced version of a paper published in Physiology. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) |
Funding Information: | Funder Grant number British Heart Foundation FS/16/42/32308 |
Depositing User: | Symplectic Publications |
Date Deposited: | 18 Jul 2018 16:16 |
Last Modified: | 13 Jun 2019 00:41 |
Status: | Published |
Publisher: | American Physiological Society |
Identification Number: | 10.1152/physiol.00016.2018 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:133424 |