Byers, R.A., Maiti, R., Danby, S.G. orcid.org/0000-0001-7363-140X et al. (6 more authors) (2017) Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography. In: Choi, B., Zeng, H. and Kollias, N., (eds.) Proceedings of SPIE. SPIE BIOS 2017, 28 Jan - 02 Feb 2017, San Francisco, California. Society of Photo-optical Instrumentation Engineers ISBN 9781510605152
Abstract
Background and Aim: With inflammatory skin conditions such as atopic dermatitis (AD), epidermal thickness is mediated by both pathological hyperplasia and atrophy such as that resulting from corticosteroid treatment. Such changes are likely to influence the depth and shape of the underlying microcirculation. Optical coherence tomography (OCT) provides a non-invasive view into the tissue, however structural measures of epidermal thickness are made challenging due to the lack of a delineated dermal-epidermal junction in AD patients. Instead, angiographic extensions to OCT may allow for direct measurement of vascular depth, potentially presenting a more robust method of estimating the degree of epidermal thickening. Methods and results: To investigate microcirculatory changes within AD patients, volumes of angiographic OCT data were collected from 5 healthy volunteers and compared to that of 5 AD patients. Test sites included the cubital and popliteal fossa, which are commonly affected by AD. Measurements of the capillary loop and superficial arteriolar plexus (SAP) depth were acquired and used to estimate the lower and upper bounds of the undulating basement membrane of the dermal-epidermal junction. Furthermore, quantitative parameters such as vessel density and diameter were derived from each dataset and compared between groups. Capillary loop depth increased slightly for AD patients at the poplitial fossa and SAP was found to be measurably deeper in AD patients at both sites, likely due to localized epidermal hyperplasia.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Editors: |
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Copyright, Publisher and Additional Information: | © 2017 SPIE. Reproduced in accordance with the publisher's self-archiving policy. |
Keywords: | Optical Coherence Tomography; Angiography; Vivosight; Atopic Dermatitis; Eczema; Speckle Variance |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Electronic and Electrical Engineering (Sheffield) The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Mechanical Engineering (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number MEDICAL RESEARCH COUNCIL MR/L012669/1 ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL (EPSRC) EP/K009699/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 09 Aug 2018 09:48 |
Last Modified: | 09 Aug 2018 09:49 |
Published Version: | https://doi.org/10.1117/12.2252407 |
Status: | Published |
Publisher: | Society of Photo-optical Instrumentation Engineers |
Refereed: | Yes |
Identification Number: | 10.1117/12.2252407 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:133308 |