Paleri, V, Sawant, R, Mehanna, H et al. (2 more authors) (2018) Laryngeal Dysplasia and narrow band imaging: secondary analysis of published data supports the role in patient follow up. Clinical otolaryngology, 43 (6). pp. 1439-1442. ISSN 1749-4478
Abstract
Background: Clinicians have recognised the role of narrow band imaging (NBI) in the management of head and neck cancer in several studies. However, a recent systematic review was unable to pool the data on diagnostic efficacy in this setting owing to the heterogeneity in the published data.
Methods: Secondary analysis of data, utilising Bayes’ theorem, from meta‐analyses and randomised trials
Results: In patients with a histological diagnosis of mild dysplasia who show no abnormalities on NBI, the post‐test probability of malignancy is 2.3%, compared to 10.3% with conventional white light imaging (WLI). For severe dysplasia, similar post‐test probabilities after NBI and WLI are 8.0% and 29.7% respectively. Post‐test probabilities in this setting indicate the chance of missing malignancy following a negative NBI or WLI in patients who undergo no further intervention. This paper also provides a nomogram designed for use in this setting.
Conclusions: This paper identifies the evidence base for use of NBI in the follow up for laryngeal dysplasia.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This article is protected by copyright. All rights reserved. This is the pre-peer reviewed version of the following article: Paleri, V, Sawant, R, Mehanna, H et al. (2018) Laryngeal Dysplasia and narrow band imaging: secondary analysis of published data supports the role in patient follow up. Clinical otolaryngology, which has been published in final form at https://doi.org/10.1111/coa.13182. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Keywords: | general; outcomes; research; systematic reviews |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Inst of Clinical Trials Research (LICTR) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 16 Jul 2018 10:16 |
Last Modified: | 29 Jun 2020 13:35 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/coa.13182 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:133301 |