Cosgrove, SC, Plane, JMC orcid.org/0000-0003-3648-6893 and Marsden, SP orcid.org/0000-0002-2723-8954 (2018) Radical-mediated direct C–H amination of arenes with secondary amines. Chemical Science, 9 (32). pp. 6647-6652. ISSN 2041-6520
Abstract
Aryl dialkyl amines, valuable subunits of a wide range of effect chemicals, are accessed by intramolecular amination of aromatic C–H bonds employing UV photolysis of N-chloroamines. The reactions show good functional group tolerance and allow access to a range of fused and bridged polycyclic structures. The homogeneous reaction conditions allow for the one-pot conversion of secondary amines to their arylated derivatives. Experimental and theoretical evidence supports the involvement of electrophilic aminium radicals which react via direct ortho-attack on the arene.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018, The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. To view a copy of this license, visit https://creativecommons.org/licenses/by/3.0/. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Physical Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 16 Jul 2018 10:41 |
Last Modified: | 23 Aug 2018 11:18 |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/C8SC01747F |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:133289 |
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