Foster, RJ orcid.org/0000-0002-5337-3615, Damion, RA orcid.org/0000-0003-2630-9914, Ries, ME orcid.org/0000-0002-8050-3200 et al. (4 more authors) (2018) Imaging of Nuclear Magnetic Resonance spin-lattice relaxation activation energy in cartilage. Royal Society Open Science, 5. 180221. ISSN 2054-5703
Abstract
Samples of human and bovine cartilage have been examined using magnetic resonance imaging to determine the proton nuclear magnetic resonance spin-lattice relaxation time, T1, as a function of depth through the cartilage tissues. T1 was measured at 5 – 7 temperatures between 8 and 38 °C. From this it is shown that the T1 relaxation time is well described by Arrhenius-type behaviour and the activation energy of the relaxation process is quantified. The activation energy within the cartilage is approximately 11±2 kJ/mol with this notably being less than that for both pure water (16.6±0.4 kJ/mol) and the phosphate-buffered solution in which the cartilage was immersed (14.7±1.0 kJ/mol). It is shown that this activation energy increases as a function of depth in the cartilage. It is known that cartilage composition varies with depth and so these results have been interpreted in terms of the structure within the cartilage tissue and the association of the water with the macromolecular constituents of the cartilage.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
Keywords: | Cartilage; Magnetic Resonance Imaging; Activation Energy; T1 |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Physics and Astronomy (Leeds) > Soft Matter Physics (Leeds) |
Funding Information: | Funder Grant number EPSRC EP/F040792/1 Wellcome Trust 088908/Z/09/Z Wellcome Trust 088908/Z/09/Z |
Depositing User: | Symplectic Publications |
Date Deposited: | 02 Jul 2018 10:02 |
Last Modified: | 16 Dec 2024 15:13 |
Status: | Published |
Publisher: | The Royal Society |
Identification Number: | 10.1098/rsos.180221 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:132801 |