Romasanta, Angelo K.S., van der Sijde, Peter, Hellsten, Iina et al. (4 more authors) (2018) When fragments link:a bibliometric perspective on the development of fragment-based drug discovery. Drug discovery today. ISSN 1359-6446
Abstract
Fragment-based drug discovery (FBDD) is a highly interdisciplinary field, rich in ideas integrated from pharmaceutical sciences, chemistry, biology, and physics, among others. To enrich our understanding of the development of the field, we used bibliometric techniques to analyze 3642 publications in FBDD, complementing accounts by key practitioners. Mapping its core papers, we found the transfer of knowledge from academia to industry. Co-authorship analysis showed that university–industry collaboration has grown over time. Moreover, we show how ideas from other scientific disciplines have been integrated into the FBDD paradigm. Keyword analysis showed that the field is organized into four interconnected practices: library design, fragment screening, computational methods, and optimization. This study highlights the importance of interactions among various individuals and institutions from diverse disciplines in newly emerging scientific fields. We study the organizational aspects of the development of fragment-based drug discovery (FBDD), using tools from bibliometrics.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Authors, 2018 |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number EUROPEAN COMMISSION 675899 |
Depositing User: | Pure (York) |
Date Deposited: | 27 Jun 2018 09:40 |
Last Modified: | 14 Nov 2024 00:28 |
Published Version: | https://doi.org/10.1016/j.drudis.2018.05.004 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1016/j.drudis.2018.05.004 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:132630 |
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