Venneri, A., Jahn-Carta, C., Marco, M.D. et al. (2 more authors) (2018) Diagnostic and prognostic role of semantic processing in preclinical Alzheimer's disease. Biomarkers in Medicine, 12 (6). ISSN 1752-0363
Abstract
Relatively spared during most of the timeline of normal aging, semantic memory shows a subtle yet measurable decline even during the pre-clinical stage of Alzheimer's disease. This decline is thought to reflect early neurofibrillary changes and impairment is detectable using tests of language relying on lexical-semantic abilities. A promising approach is the characterization of semantic parameters such as typicality and age of acquisition of words, and propositional density from verbal output. Seminal research like the Nun Study or the analysis of the linguistic decline of famous writers and politicians later diagnosed with Alzheimer's disease supports the early diagnostic value of semantic processing and semantic memory. Moreover, measures of these skills may play an important role for the prognosis of patients with mild cognitive impairment.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Future Medicine. This is an author produced version of a paper subsequently published in Biomarkers in Medicine. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Alzheimer's disease; Category Fluency task; linguistic attainment; mild cognitive impairment; neuropsychological markers; semantic memory |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 29 Jun 2018 12:38 |
Last Modified: | 17 Apr 2024 13:13 |
Status: | Published |
Publisher: | Future Medicine |
Refereed: | Yes |
Identification Number: | 10.2217/bmm-2017-0324 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:132620 |