Giollo, A, Bissell, L-A orcid.org/0000-0002-2789-4652 and Buch, MH orcid.org/0000-0002-8962-5642 (2018) Cardiovascular risk factors in patients with rheumatoid arthritis prescribed disease modifying anti-rheumatic drugs. Expert Opinion on Drug Safety, 17 (7). pp. 697-708. ISSN 1474-0338
Abstract
Introduction: Rheumatoid arthritis (RA) is associated with a heightened risk of cardiovascular disease (CVD), with both traditional CV risk factors and inflammation contributing to this risk.
Areas covered: This review highlights the burden of CVD in RA and associated traditional CV risk factors, including the complexity of dyslipidemia in RA and the so-called ‘lipid paradox.’ Furthermore, the recognized RA-disease-specific factors associated with higher risk of CVD and the role of systemic inflammation in the pathogenesis of CVD in RA will be addressed. With the advent of biologic and targeted synthetic therapies in the treatment of RA, the effect of conventional and newer generation disease modifying anti-rheumatic therapies (DMARDs) on CV risk and associated risk factors will also be discussed.
Expert opinion: Identifying the RA phenotype at greatest risk of CVD, understanding the interplay of increased traditional risk factors, common inflammatory processes and RA-specific factors, and personalized use of DMARDs according to disease phenotype and comorbidity to reduce this risk are key areas for future research.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Biologic agents, cardiovascular disease, cardiovascular risk factors, DMARDs, rheumatoid arthritis |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 21 Jun 2018 12:57 |
Last Modified: | 15 Aug 2018 14:41 |
Status: | Published |
Publisher: | Taylor & Francis |
Identification Number: | 10.1080/14740338.2018.1483331 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:132342 |