Meineke, J., Wenzel, F., de Marco, M. et al. (5 more authors) (2018) Motion artifacts in standard clinical setting obscure disease-specific differences in quantitative susceptibility mapping. Physics in Medicine & Biology, 63 (14). ISSN 0031-9155
Abstract
PURPOSE: As Quantitative Susceptibility Mapping (QSM) is maturing, more clinical applications are being explored. With this comes the question whether QSM is sufficiently robust and reproducible to be directly used in a clinical setting where patients are possibly not cooperative and/or unable to suppress involuntary movements sufficiently. Subjects and Methods: Twenty-nine patients with Alzheimer's Disease (AD), 31 patients with Mild Cognitive Impairment (MCI) and 41 healthy controls (HC) were scanned on a 3T scanner, including a multi-echo gradient-echo sequence for QSM and an inversion-prepared segmented gradient-echo sequence (T1-TFE, MPRAGE). The severity of motion artifacts (excessive/strong /noticeable/invisible) was categorized via visual inspection by two independent raters. Quantitative susceptibility was reconstructed using "Joint background-field removal and segmentation-Enhanced Dipole Inversion" (JEDI), based on segmented subcortical gray-matter regions, as well as using "Morphology Enabled Dipole Inversion" (MEDI). Statistical analysis of the susceptibility maps was performed per region. Results: A large fraction of the data showed motion artifacts, visible in both magnitude images and susceptibility maps. No statistically significant susceptibility differences were found between groups including motion-affected data. Considering only subjects without visible motion, a significant susceptibility differences were observed in caudate nucleus as well as in putamen. Conclusion: Motion-effects can obscure statistically significant differences in QSM between patients and controls. Additional measures to restrict and/or compensate for subject motion should be taken for QSM in standard clinical settings to avoid risk of false findings.
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Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 IOP Publishing. This is an author produced version of a paper subsequently published in Physics in Medicine and Biology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | alzheimer's disease; magnetic resonance imaging; motion artefacts; quantitative susceptibility mapping |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 19 Jun 2018 12:30 |
Last Modified: | 15 Jul 2020 10:14 |
Published Version: | https://doi.org/10.1088/1361-6560/aacc52 |
Status: | Published |
Publisher: | IOP Publishing |
Refereed: | Yes |
Identification Number: | 10.1088/1361-6560/aacc52 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:132158 |
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