Simsek, A., Aldamanhori, R., Chapple, C.R. orcid.org/0000-0002-2960-9931 et al. (1 more author) (2018) Overcoming scarring in the urethra: Challenges for tissue engineering. Asian Journal of Urology, 5 (2). pp. 69-77. ISSN 2214-3882
Abstract
Urethral stricture disease is increasingly common occurring in about 1% of males over the age of 55. The stricture tissue is rich in myofibroblasts and multi-nucleated giant cells which are thought to be related to stricture formation and collagen synthesis. An increase in collagen is associated with the loss of the normal vasculature of the normal urethra. The actual incidence differs based on worldwide populations, geography, and income. The stricture aetiology, location, length and patient's age and comorbidity are important in deciding the course of treatment. In this review we aim to summarise the existing knowledge of the aetiology of urethral strictures, review current treatment regimens, and present the challenges of using tissue-engineered buccal mucosa (TEBM) to repair scarring of the urethra. In asking this question we are also mindful that recurrent fibrosis occurs in other tissues-how can we learn from these other pathologies?
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2018 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | Augmentation urethroplasty; Fibrosis; Tissue-engineered buccal mucosa; Urethral strictures |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Materials Science and Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 18 Jun 2018 15:19 |
Last Modified: | 21 Jun 2018 04:48 |
Published Version: | https://doi.org/10.1016/j.ajur.2018.02.002 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.ajur.2018.02.002 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:131902 |
Download
Filename: Overcoming scarring in the urethra: Challenges for tissue engineering.pdf
Licence: CC-BY-NC-ND 4.0