Williams, U. orcid.org/0000-0001-7120-2572, Bandmann, O. orcid.org/0000-0003-3149-0252 and Walker, R. (2018) Parkinson's disease in Sub-Saharan Africa: A review of epidemiology, genetics and access to care. Journal of Movement Disorders, 11 (2). pp. 53-64. ISSN 2005-940X
Abstract
A low prevalence of Parkinson's disease (PD) has been reported in the Sub-Saharan Africa (SSA) region. The genetic causes and clinical features of PD in this region have been poorly described. Very few reports have examined the availability and access to evidence-based quality care for people living with PD in this region. We reviewed all publications focusing on idiopathic PD from SSA published up to May 2016 and observed a prevalence of PD ranging from 7/100,000 in Ethiopia to 67/100,000 in Nigeria. The most recent community-based study reported a mean age at onset of 69.4 years. The infrequent occurrence of mutations in established PD genes was also observed in the region. Treatments were non-existent or at best irregular. Additionally, there is a lack of well-trained medical personnel and multidisciplinary teams in most countries in this region. Drugs for treating PD are either not available or unaffordable. Large-scale genetic and epidemiological studies are therefore needed in SSA to provide further insights into the roles of genetics and other etiological factors in the pathogenesis of PD. The quality of care also requires urgent improvement to meet the basic level of care required by PD patients.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 The Korean Movement Disorder Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Parkinson’s disease; Sub-Saharan Africa; access to care.; epidemiology; genetics |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 15 Jun 2018 15:29 |
Last Modified: | 16 Jun 2018 05:12 |
Published Version: | https://doi.org/10.14802/jmd.17028 |
Status: | Published |
Publisher: | Korean Movement Disorders Society |
Refereed: | Yes |
Identification Number: | 10.14802/jmd.17028 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:131864 |
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Filename: Uduak Williams, PD in Africa, JMD 2018.pdf
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