Wang, Z, McGlynn, KA, Rajpert-De Meyts, E et al. (21 more authors) (2017) Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor. Nature Genetics, 49 (7). pp. 1141-1147. ISSN 1061-4036
Abstract
The international Testicular Cancer Consortium (TECAC) combined five published genome-wide association studies of testicular germ cell tumor (TGCT; 3,558 cases and 13,970 controls) to identify new susceptibility loci. We conducted a fixed-effects meta-analysis, including, to our knowledge, the first analysis of the X chromosome. Eight new loci mapping to 2q14.2, 3q26.2, 4q35.2, 7q36.3, 10q26.13, 15q21.3, 15q22.31, and Xq28 achieved genome-wide significance (P < 5 × 10−8). Most loci harbor biologically plausible candidate genes. We refined previously reported associations at 9p24.3 and 19p12 by identifying one and three additional independent SNPs, respectively. In aggregate, the 39 independent markers identified to date explain 37% of father-to-son familial risk, 8% of which can be attributed to the 12 new signals reported here. Our findings substantially increase the number of known TGCT susceptibility alleles, move the field closer to a comprehensive understanding of the underlying genetic architecture of TGCT, and provide further clues to the etiology of TGCT.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2017 Nature America, Inc., part of Springer Nature. This is an author produced version of a paper published in Nature Genetics. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Genome-wide association studies; Germline development; Testicular cancer |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Epidemiology and Biostatistics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 31 May 2018 10:22 |
Last Modified: | 31 May 2018 10:22 |
Status: | Published |
Publisher: | Nature Publishing Group |
Identification Number: | 10.1038/ng.3879 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:131470 |