Mohammedeid, A.M., Lukashchuk, V. and Ning, K. (2014) Protein aggregation and Arfaptin2: A novel therapeutic target against neurodegenerative diseases. New Horizons in Translational Medicine, 2 (1). pp. 12-15.
Abstract
Therapeutic targets for neurodegenerative conditions are constantly emerging. Diseases such as amyotrophic lateral sclerosis and Huntington's disease are multifactorial and involve dysfunction of various cellular pathways. Protein aggregate formation is one of t h e crucial pathological signs of cellular dysfunction, and is characteristic of many neurodegenerative conditions. Proteins recruited to these aggregates are thought to play a role in formation of the pathogenic inclusions. This review aims at exploring the current evidence for protein aggregation and t h e role for Arfaptin2, as a candidate factor contributing to t h e formation of aggresomes and a potential therapeutic target in motor neuron disease.
Metadata
| Item Type: | Article |
|---|---|
| Authors/Creators: |
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| Copyright, Publisher and Additional Information: | © 2014 European Society for Translational Medicine. |
| Keywords: | Amyotrophic lateral sclerosis; Arfaptin2; Huntington’s disease; Motor neuron disease; Neurodegenerative disease; Protein aggregation; Protein degradation |
| Dates: |
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| Institution: | The University of Sheffield |
| Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
| Depositing User: | Symplectic Sheffield |
| Date Deposited: | 29 Oct 2018 12:11 |
| Last Modified: | 29 Oct 2018 12:11 |
| Published Version: | http://doi.org/10.1016/j.nhtm.2014.08.004 |
| Status: | Published |
| Publisher: | Elsevier |
| Refereed: | Yes |
| Identification Number: | 10.1016/j.nhtm.2014.08.004 |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:131409 |
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)