Sleger, T., Gangl, E., Pop-Damkov, P. et al. (4 more authors) (2018) Efficacy of ceftazidime-avibactam in a rat intra-abdominal abscess model against a ceftazidime- and meropenem-resistant isolate of Klebsiella pneumoniae carrying blaKPC-2. Journal of Chemotherapy , 30 (2). pp. 95-100. ISSN 1120-009X
Abstract
Efficacies of ceftazidime-avibactam (4:1 w/w) and ceftazidime were tested against ceftazidime-susceptible (blaKPC-2-negative), and meropenem- and ceftazidime-resistant (blaKPC-2-positive), Klebsiella pneumoniae in a 52-h, multiple dose, abdominal abscess model in the rat. Efficacies corresponded to minimum inhibitory concentrations (MICs) measured in vitro and were consistent with drug exposures modelled from pharmacokinetics in infected animals. The ceftazidime, ceftazidime-avibactam and meropenem control treatments were effective in the rat abscess model against the susceptible strain, whereas only ceftazidime-avibactam was effective against K. pneumoniae harbouring blaKPC-2.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Edizioni Scientifiche per l'Informazione su Farmaci e Terapia. This is an author-produced version of a paper subsequently published in Journal of Chemotherapy. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Ceftazidime–avibactam; Abscess infection; KPC; Klebsiella pneumoniae; Rat pharmacokinetics |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Mathematics and Statistics (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 01 Jun 2018 11:47 |
Last Modified: | 09 Apr 2024 15:57 |
Status: | Published |
Publisher: | Taylor & Francis |
Refereed: | Yes |
Identification Number: | 10.1080/1120009X.2017.1405609 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:131151 |