Bradburn, M.J. orcid.org/0000-0002-3783-9761, Altman, D.G., Smith, P. et al. (2 more authors) (1998) Time trends in breast cancer survival: experience in a single centre, 1975-89. British Journal of Cancer, 77 (11). pp. 1944-1949. ISSN 0007-0920
Abstract
The aim of this retrospective cohort study was to investigate whether survival of patients with breast cancer has changed over the period 1975-89. A total of 2604 women diagnosed as having invasive breast cancer at a clinical oncology unit in London were followed up for between 5 and 20 years. Patients were divided into four groups according to menstrual status (pre or post) and the staging of cancer (operable or inoperable). For each group, survival from diagnosis was compared between three consecutive 5-year cohorts, both with and without adjustments made for relevant prognostic factors. No temporal patterns were found in patients with inoperable cancer, in whom the survival rate was consistently low. Of women with operable cancers, differences were seen only among post-menopausal women, for whom the best survival patterns were seen in patients diagnosed between 1985-89. This is probably due to tamoxifen being commonly prescribed as adjuvant treatment for this cohort of patients. We cannot explain an apparently worse survival in the group of patients presenting in the early 1980s compared with that observed in the late 1970s.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 1998 Cancer Research Campaign. Reproduced in accordance with the publisher's self-archiving policy. Available under a Creative Commons Attribution Non-Commercial Share Alike License. |
Keywords: | breast cancer; survival; time trend; mortality; England; rates; Wales |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 18 Jun 2018 13:57 |
Last Modified: | 21 Jun 2018 05:28 |
Published Version: | https://www.nature.com/articles/bjc1998322 |
Status: | Published |
Publisher: | Cancer Research UK |
Refereed: | Yes |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:130952 |
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