Gibson, PS, Quaglia, A, Dhawan, A et al. (5 more authors) (2018) Vitamin D status and associated genetic polymorphisms in a cohort of UK children with non‐alcoholic fatty liver disease. Pediatric Obesity, 13 (7). pp. 433-441. ISSN 2047-6302
Abstract
Background: Vitamin D deficiency has been associated with non‐alcoholic fatty liver disease (NAFLD). However, the role of polymorphisms determining vitamin D status remains unknown.
Objectives: The objectives of this study were to determine in UK children with biopsy‐proven NAFLD (i) their vitamin D status throughout a 12‐month period and (ii) interactions between key vitamin D‐related genetic variants (nicotinamide adenine dinucleotide synthase‐1/dehydrocholesterol reductase‐7, vitamin D receptor, group‐specific component, CYP2R1) and disease severity.
Methods: In 103 paediatric patients with NAFLD, serum 25‐hydroxyvitamin D (25OHD) levels and genotypes were determined contemporaneously to liver biopsy and examined in relation to NAFLD activity score and fibrosis stage.
Results: Only 19.2% of children had adequate vitamin D status; most had mean 25OHD levels considered deficient (<25 nmol·L⁻¹, 25.5%) or insufficient (<50 nmol·L⁻¹, 55.3%). Patients had significantly lower 25OHD levels in winter months (95% CI: 22.7–31.2 nmol·L⁻¹) when compared with spring (30.5–42.1 nmol·L⁻¹; P = 0.0089), summer (36.3–47.2 nmol·L⁻¹; P < 0.0001) and autumn (34.2–47.5 nmol·L⁻¹; P = 0.0003). Polymorphisms in the nicotinamide adenine dinucleotide synthase‐1/dehydrocholesterol reductase‐7 (rs3829251, rs12785878) and vitamin D receptor (rs2228570) genes were independently associated with increased steatosis; while a group‐specific component variant (rs4588) was associated with increased inflammation in liver biopsies.
Conclusions: Children with NAFLD in the UK have particularly low winter vitamin D status, with vitamin D insufficiency prevalent throughout the year. Polymorphisms in the vitamin D metabolic pathway are associated with histological severity of paediatric NAFLD.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 The Authors. Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0/. |
Keywords: | 25OHD; genotype; non‐alcoholic fatty liver disease; vitamin D |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 16 May 2018 13:57 |
Last Modified: | 25 Jun 2023 21:21 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/ijpo.12293 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:130854 |