Lees, T, Cullinane, A, Condon, A et al. (3 more authors) (2018) Characterising the adipose-inflammatory microenvironment in male breast cancer. Endocrine-Related Cancer, 25 (7). pp. 773-781. ISSN 1351-0088
Abstract
Male breast cancer (MBC) incidence seems to parallel global increases in obesity. The stromal microenvironment contributes to carcinogenesis, yet the role of adipocytes in this is understudied in MBC. We identified 4 cohorts of male breast tissues diagnosed when obesity was rare (archival cohort) and more common (contemporary cohort). We examined the microenvironment of archival and contemporary cohorts of MBC, diagnosed 1940 - 1970 and 1998 - 2006, respectively, with 2 cohorts of, archival and contemporary gynaecomastia, diagnosed 1940 - 1979 and 1996 - 2011, respectively serving as controls. We quantified adipocytes, crown-like structures (CLS) and the presence of CD8, αSMA and CD68+ macrophages in both cohorts, and determined how these affected survival, in the contemporary MBC cohort. In both MBC cohorts, mean adipocyte diameter was larger in the distant stroma compared with stroma close to the invading tumour (92.2 µm vs 66.7 µm). This was not seen in gynaecomastia. CLS were more frequent in both MBC cohorts than gynaecomastia (44/55 [80%] vs 11/18 [61%], p < 0.001). No relationship was found between CLS number and adipocyte size, although there were greater numbers of CLS in contemporary MBC > archival MBC > gynaecomastia. CD8 and CD68 expression in the stroma was significantly associated with reduced survival, with no effects seen with αSMA. Changes in the adipose-inflammatory microenvironment may be a contributing factor to the increase seen in MBC diagnosis.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2018 Society for Endocrinology, Published by Bioscientifica Ltd. Disclaimer: this is not the definitive version of record of this article.This manuscript has been accepted for publication in Endocrine-Related Cancer, but the version presented here has not yet been copy-edited, formatted or proofed. Consequently, Bioscientifica accepts no responsibility for any errors or omissions it may contain. The definitive version is now available at http://doi.org/10.1530/ERC-17-0407 |
Keywords: | male breast cancer; gynaecomastia; adipocytes; crown-like structures; microenvironment |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Pathology & Tumour Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 May 2018 10:30 |
Last Modified: | 09 May 2019 00:42 |
Status: | Published |
Publisher: | BioScientifica |
Identification Number: | 10.1530/ERC-17-0407 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:130754 |