Morgentin, R, Dow, M, Aimon, A et al. (5 more authors) (2018) Translation of Innovative Chemistry into Screening Libraries: An Exemplar Partnership from the European Lead Factory. Drug Discovery Today, 23 (9). pp. 1578-1583. ISSN 1359-6446
Abstract
The identification of high-quality starting points for drug discovery is an enduring challenge in medicinal chemistry. Yet, the chemical space explored in discovery programmes tends be limited by the narrow toolkit of robust methods that are exploited in discovery workflows. The European Lead Factory (ELF) was established in 2013 to boost early-stage drug discovery within Europe. In this Feature, we describe an exemplar partnership that has led to the addition of 21 119 distinctive screening compounds to the ELF Joint European Compound Library. The partnership could serve as a blueprint for the translation of innovative academic chemistry into discovery programmes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Elsevier Ltd. This is an author produced version of a paper published in Drug Discovery Today. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Chemical diversity; chemistry method translation; natural-product-like |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Funding Information: | Funder Grant number EU - European Union 115489-EUC2LID |
Depositing User: | Symplectic Publications |
Date Deposited: | 11 May 2018 10:23 |
Last Modified: | 09 May 2019 00:42 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.drudis.2018.05.007 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:130638 |