Coates, LC orcid.org/0000-0002-4756-663X, Tillett, W, Shaddick, G et al. (3 more authors) (2018) Value of the Routine Assessment of Patient Index Data 3 in Patients With Psoriatic Arthritis: Results From a Tight‐Control Clinical Trial and an Observational Cohort. Arthritis Care and Research, 70 (8). pp. 1198-1205. ISSN 2151-464X
Abstract
Objective
To analyze RAPID3, a patient‐reported, composite index, designed initially for feasibility in clinical care. RAPID3 was developed in rheumatoid arthritis, but has been found useful in many rheumatic diseases. We analysed RAPID3 in patients with psoriatic arthritis (PsA).
Methods
Post‐hoc analyses were performed on two independent datasets, the tight control of PsA (TICOPA) clinical trial, and the long‐term outcome in PsA study (LOPAS II), an observational cohort. RAPID3 (0‐30) is the total of three 0‐10 scores for HAQ‐DI (recalculated from 0‐3), pain visual analog scale (VAS), and global VAS. RAPID3 scores were compared to the PsA disease activity score (PASDAS) and disease activity in psoriatic arthritis (DAPSA) and other available clinical measures, according to Spearman correlation coefficients, standardised response mean (SRM), standard error of the mean (SEM), smallest detectible difference (SDD), minimally important difference (MID in patients who improved) and receiver‐operating characteristic (ROC) curves. RAPID3 remission was compared to criteria for both standard minimal disease activity (MDA) and very low disease activity (VLDA).
Results
RAPID3 was correlated significantly with PASDAS in TICOPA (r=0.79, p<0.01) and with DAPSA in LOPAS (rho=0.59, p<0.01), and with most other measures in both datasets. RAPID3 discriminated between tight control and standard care in TICOPA at 48 weeks at levels comparable to DAPSA and the PASDAS (p<0.01). RAPID3 remission discriminated treatment groups in TICOPA intermediate between MDA and VLDA criteria.
Conclusion
RAPID3 appears comparably informative to PASDAS and DAPSA in PsA, with greater feasibility for routine clinical care.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2017, American College of Rheumatology. This is the peer reviewed version of the following article: 'Coates, LC , Tillett, W, Shaddick, G et al (2018). Value of the Routine Assessment of Patient Index Data 3 in Patients With Psoriatic Arthritis: Results From a Tight‐Control Clinical Trial and an Observational Cohort. Arthritis Care and Research, 70 (8). pp. 1198-1205', which has been published in final form at https://doi.org/10.1002/acr.23460. This article may be used for non-commercial purposes in accordance with the Wiley Terms and Conditions for Self-Archiving. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) |
Funding Information: | Funder Grant number Arthritis Research UK MP/18825 |
Depositing User: | Symplectic Publications |
Date Deposited: | 22 May 2018 12:05 |
Last Modified: | 07 Nov 2018 01:39 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/acr.23460 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:130612 |