Horsburgh, K., Wardlaw, J.M., van Agtmael, T. et al. (43 more authors) (2018) Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clinical Science, 132 (8). pp. 851-868. ISSN 0143-5221
Abstract
Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society. |
Keywords: | cerebral vascular disease; dementia |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield) |
Funding Information: | Funder Grant number MEDICAL RESEARCH COUNCIL MR/M013553/1 ALZHEIMERS RESEARCH UK ARUK-IRG2014-10 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 09 May 2018 14:04 |
Last Modified: | 12 Apr 2024 15:31 |
Status: | Published |
Publisher: | Portland Press |
Refereed: | Yes |
Identification Number: | 10.1042/CS20171620 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:130520 |