Yu, M., Omar, C., Schmidt, A. et al. (2 more authors) (2018) Improving feeding powder distribution to the compaction zone in the roller compaction. European Journal of Pharmaceutics and Biopharmaceutics, 128. pp. 57-68. ISSN 1873-3441
Abstract
In the roller compaction process, powder flow properties have a significant influence on the uniformity of the ribbon properties. The objective of this work was to improve the powder flow in the feeding zone by developing novel feeding guiders which are located in the feeding zone close to the rollers in the roller compactor (side sealing system). Three novel feeding guiders were designed by 3D printing and used in the roller compactor, aiming to control the amount of powder passing across the roller width. The new feeding guiders were used to guide more powder to the sides between the rollers and less powder to the centre comparing to the original feeding elements. Temperature profile and porosity across the ribbon width indicated the uniformity of the ribbon properties. Using the novel feeding guiders resulted in producing ribbons with uniform temperature profile and porosity distribution across the ribbon width. The design of the feeding guiders contributed to improving the tensile strength of the ribbons produced from the compaction stage as well as reducing the fines produced from the crushing stage.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Elsevier |
Keywords: | Roller compaction; Ribbon uniformity; Feeding guider; Temperature; Fines |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Chemical and Biological Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 04 May 2018 09:56 |
Last Modified: | 18 Apr 2024 07:50 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.ejpb.2018.04.015 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:130421 |