Smith, L orcid.org/0000-0002-4280-6323, Glaser, AW, Kinsey, SE et al. (4 more authors) (2018) Long‐term survival after childhood acute lymphoblastic leukaemia: population‐based trends in cure and relapse by clinical characteristics. British Journal of Haematology, 182 (6). pp. 851-858. ISSN 0007-1048
Abstract
‘Cure models’ offer additional information to traditional approaches to assess survival for cancer patients by simultaneously estimating the proportion cured and the survival of those ‘uncured’. The proportion cured is a summary of long term survival while the median survival time of the uncured provides important information on those who are not long-term survivors. Population-based trends in the cure proportion and survival of the uncured for childhood acute lymphoblastic leukaemia (ALL) by clinical prognostic risk factors were estimated using flexible parametric cure models, based on overall survival and event-free survival. Children aged 1-17 years diagnosed from 1990-2011 in Yorkshire, UK, were included (n=492). The percentage cured increased from 77% (95%CI 70-84%) in 1990-1997 to 89% (84-93%) in 2003-2011, while the median survival time of the uncured decreased from 3.2 years (2.2-4.1 years) to 0.7 years (0-1.5 years). Models based on event-free survival showed a similar trend. The 5-year cumulative incidence of relapse substantially decreased from 35% in 1990-97 to 9% in 2003-2011. These results show selective improvement in survival between 1990 and 2011 with a significant reduction in the risk of relapse alongside a reduced absolute duration of survival for those destined to be uncured.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2018 John Wiley & Sons Ltd, British Journal of Haematology. This is the peer reviewed version of the following article: Smith, L , Glaser, AW, Kinsey, SE et al. (2018) Long-term survival after childhood acute lymphoblastic leukaemia: population-based trends in cure and relapse by clinical characteristics. British Journal of Haematology. which has been published in final form at https://doi.org/10.1111/bjh.15424. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Keywords: | acute lymphoblastic leukaemia, cure, survival, event-free survival |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Epidemiology and Biostatistics (Leeds) |
Funding Information: | Funder Grant number Candlelighters No Ext Ref Laura Crane Trust No Ext Ref |
Depositing User: | Symplectic Publications |
Date Deposited: | 03 May 2018 11:00 |
Last Modified: | 29 May 2019 00:43 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/bjh.15424 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:130395 |