Alkharobi, HE, Al-Khafaji, H, Beattie, J orcid.org/0000-0002-1308-6603 et al. (2 more authors) (2018) Insulin-Like Growth Factor Axis Expression in Dental Pulp Cells Derived From Carious Teeth. Frontiers in Bioengineering and Biotechnology, 6. 36. ISSN 2296-4185
Abstract
The insulin-like growth factor (IGF) axis plays an important role in dental tissue regeneration and most components of this axis are expressed in human dental pulp cells (DPCs). In our previous study, we analyzed IGF axis gene expression in DPCs and demonstrated a novel role of IGF binding protein (IGFBP)-2 and -3 in coordinating mineralized matrix formation in differentiating DPCs. A more recent study from our laboratory partially characterized dental pulp stem cells from teeth with superficial caries (cDPCs) and showed that their potential to differentiate odontoblasts and/or into osteoblasts is enhanced by exposure to the mild inflammatory conditions characteristic of superficial caries. In the present study, we examine whether changes apparent in IGF axis expression during osteogenic differentiation of healthy DPCs are also apparent in DPCs derived from carious affected teeth.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Alkharobi, Al-Khafaji, Beattie, Devine and El-Gendy. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
Keywords: | insulin-like growth factor axis; IGF binding protein-3; IGF binding proteins-2; dental pulp stem cells; inflammation; pulp regeneration; caries; dentin |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 03 May 2018 16:34 |
Last Modified: | 25 Jun 2023 21:20 |
Status: | Published |
Publisher: | Frontiers Media |
Identification Number: | 10.3389/fbioe.2018.00036 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:130378 |