Wang, Han I orcid.org/0000-0002-3521-993X, Roman, Eve orcid.org/0000-0001-7603-3704, Crouch, Simon orcid.org/0000-0002-3026-2859 et al. (4 more authors) (2018) A Generic Model for Follicular Lymphoma: Predicting Cost, Life Expectancy, and Quality-Adjusted-Life-Year Using UK Population–Based Observational Data. Value in Health. pp. 1176-1185. ISSN 1524-4733
Abstract
Objectives To use real-world data to develop a flexible generic decision model to predict cost, life expectancy, and quality-adjusted life-years (QALYs) for follicular lymphoma (FL) in the general patient population. Methods All patients newly diagnosed with FL in the UK’s population-based Haematological Malignancy Research Network (www.hmrn.org) between 2004 and 2011 were followed until 2015 (N = 740). Treatment pathways, QALYs, and costs were incorporated into a discrete event simulation to reflect patient heterogeneity, including age and disease management. Two scenario analyses, based on the latest National Institute for Health and Clinical Excellence (NICE) guidelines (rituximab induction therapy for newly diagnosed asymptomatic patients and rituximab maintenance therapy for patients between treatments), were conducted and their economic impacts were compared to current practice. Results Incidence-based analysis revealed expected average lifetime costs ranging from £6,165 [US$7,709] to £63,864 [US$79,862] per patient, and average life expectancy from 75 days to 17.56 years. Prevalence-based analysis estimated average annual treatment costs of £60–65 million [US$75-80 million], accounting for approximately 10% of the United Kingdom’s annual National Health Service budget for hematological cancers as a whole. Assuming that treatment effects reported in trials are applicable to all patient groups, scenario analyses for two recent NICE guidelines demonstrated potential annual cost savings for the United Kingdom that ranged with uptake frequency from £0.6 million to £11 million [US$0.75-2.75 million]. Conclusions Costs, survival, and QALYs associated with FL vary markedly with patient characteristics and disease management. Allowing the production of more realistic outcomes across the patient population as a whole, our model addresses this heterogeneity and is a useful tool with which to evaluate new technologies/treatments to support healthcare decision makers.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018, International Society for Pharmacoeconomics and Outcomes Research (ISPOR) |
Keywords: | cost,cost-effectiveness analysis,discrete event simulation,economic evaluation,follicular lymphoma,patient level simulation,Quality-Adjusted Life Years,Humans,Lymphoma, Follicular/economics,Middle Aged,Decision Support Techniques,Male,Population Surveillance/methods,Statistics as Topic/methods,Cost-Benefit Analysis/methods,Forecasting,United Kingdom/epidemiology,Aged, 80 and over,Adult,Female,Aged,Life Expectancy/trends |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Health Sciences (York) |
Depositing User: | Pure (York) |
Date Deposited: | 02 May 2018 09:10 |
Last Modified: | 16 Oct 2024 14:42 |
Published Version: | https://doi.org/10.1016/j.jval.2018.03.007 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.jval.2018.03.007 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:130349 |
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Description: A Generic Model for Follicular Lymphoma Predicting Cost Life
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