Clark, E and Peel, AD orcid.org/0000-0002-9914-3508 (2018) Evidence for the temporal regulation of insect segmentation by a conserved sequence of transcription factors. Development, 145 (10). dev155580. ISSN 0950-1991
Abstract
Long-germ insects, such as the fruit fly Drosophila melanogaster, pattern their segments simultaneously, whereas short-germ insects, such as the beetle Tribolium castaneum, pattern their segments sequentially, from anterior to posterior. Although the two modes of segmentation at first appear quite distinct, much of this difference might simply reflect developmental heterochrony. We now show here that, in both Drosophila and Tribolium, segment patterning occurs within a common framework of sequential Caudal, Dichaete and Odd-paired expression. In Drosophila, these transcription factors are expressed like simple timers within the blastoderm, whereas in Tribolium they form wavefronts that sweep from anterior to posterior across the germband. In Drosophila, all three are known to regulate pair-rule gene expression and influence the temporal progression of segmentation. We propose that these regulatory roles are conserved in short-germ embryos, and that therefore the changing expression profiles of these genes across insects provide a mechanistic explanation for observed differences in the timing of segmentation. In support of this hypothesis, we demonstrate that Odd-paired is essential for segmentation in Tribolium, contrary to previous reports.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
Keywords: | Drosophila; Gene regulatory network; Pair-rule genes; Patterning; Segmentation; Tribolium |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biology (Leeds) |
Funding Information: | Funder Grant number European Commission Research Executive Agency PCIG12-GA-2012-333650 EU - European Union 333650 BBSRC BB/L020092/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 02 May 2018 13:06 |
Last Modified: | 25 Jun 2023 21:19 |
Status: | Published |
Publisher: | Company of Biologists |
Identification Number: | 10.1242/dev.155580 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:130347 |
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