Iqbal, A. orcid.org/0000-0002-5648-0539, Novodvorsky, P. and Heller, S.R. orcid.org/0000-0002-2425-9565 (2018) Recent Updates on Type 1 Diabetes Mellitus Management for Clinicians. Diabetes and Metabolism Journal, 42 (1). pp. 3-18. ISSN 2233-6079
Abstract
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune condition that requires life-long administration of insulin. Optimal management of T1DM entails a good knowledge and understanding of this condition both by the physician and the patient. Recent introduction of novel insulin preparations, technological advances in insulin delivery and glucose monitoring, such as continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring and improved understanding of the detrimental effects of hypoglycaemia and hyperglycaemia offer new opportunities and perspectives in T1DM management. Evidence from clinical trials suggests an important role of structured patient education. Our efforts should be aimed at improved metabolic control with concomitant reduction of hypoglycaemia. Despite recent advances, these goals are not easy to achieve and can put significant pressure on people with T1DM. The approach of physicians should therefore be maximally supportive. In this review, we provide an overview of the recent advances in T1DM management focusing on novel insulin preparations, ways of insulin administration and glucose monitoring and the role of metformin or sodium-glucose co-transporter 2 inhibitors in T1DM management. We then discuss our current understanding of the effects of hypoglycaemia on human body and strategies aimed at mitigating the risks associated with hypoglycaemia.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Korean Diabetes Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Artificial pancreas device systems; Blood glucose self-monitoring; Continuous glucose monitoring; Continuous subcutaneous insulin infusion; Diabetes mellitus type 1; Hypoglycemia; Impaired awareness of hypoglycaemia; Severe hypoglycaemia; Structured education |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 01 May 2018 13:16 |
Last Modified: | 03 May 2018 05:39 |
Published Version: | https://doi.org/10.4093/dmj.2018.42.1.3 |
Status: | Published |
Publisher: | Korean Diabetes Association |
Refereed: | Yes |
Identification Number: | 10.4093/dmj.2018.42.1.3 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:130248 |
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Filename: Recent Updates on Type 1 Diabetes Mellitus Management for Clinicians.pdf
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