Hutchins, G orcid.org/0000-0002-1707-4415 and Grabsch, HI (2018) How to make tissue microarrays. Diagnostic Histopathology, 24 (4). pp. 127-135. ISSN 1756-2317
Abstract
It is now almost 20 years since tissue microarrays (TMAs) were first described by Kononen and colleagues. Today, this high throughput methodology has been widely adopted by investigators who require a cost-effective method to rapidly and simultaneously interrogate large numbers of samples, including those derived from large patient cohorts. Drawing on over 15 years of direct experience of TMA design, construction and analysis, we discuss a variety of TMA applications and provide a detailed description of TMA design, quality control and construction. Advantages and disadvantages are discussed and potential problems and practical solutions are highlighted.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2018 Published by Elsevier Ltd. This is an author produced version of a paper published in Diagnostic Histopathology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | construction; design; quality control; tissue microarray |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Pathology & Tumour Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 18 Apr 2018 14:18 |
Last Modified: | 17 Mar 2019 01:39 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.mpdhp.2018.02.008 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:129635 |