Glioma Through the Looking GLASS: Molecular Evolution of Diffuse Gliomas and the Glioma Longitudinal AnalySiS Consortium

Abstract

Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas (TCGA) and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant cellular and molecular evolution during disease progression. We review the current knowledge on the genomic and epigenetic abnormalities in primary tumors and after disease recurrence, highlight the gaps in the literature, and elaborate on the need for a new multi-institutional effort to bridge these knowledge gaps and how the Glioma Longitudinal AnalySiS Consortium (GLASS) aims to systemically catalog the longitudinal changes in gliomas. The GLASS initiative will provide essential insights into the evolution of glioma toward a lethal phenotype, with the potential to reveal targetable vulnerabilities, and ultimately, improved outcomes for a patient population in need.

Metadata

Item Type:	Article
Authors/Creators:	Aldape, K Amin, SB Ashley, DM Barnholtz-Sloan, JS Bates, AJ Beroukhim, R Bock, C Brat, DJ Claus, EB Costello, JF De Groot, JF Finocchiaro, G French, PJ Gan, HK Griffith, B Herold-Mende, CC Horbinski, C Iavarone, A Kalkanis, SN Karabatsou, K Kim, H Kouwenhoven, MCM McDonald, KL Miletic, H Nam, D-H Ng, HK Niclou, SP Noushmehr, H Ormond, R Poisson, LM Reifenberger, G Roncaroli, F Sa, JK Sillevis Smitt, PAE Smits, M Souza, CF Tabatabai, G Van Meir, EG Verhaak, RGW Watts, C Wesseling, P Woehrer, A Yung, WKA Jungk, C Hau, AC Van Dyck, E Westerman, BA Yin, J Abiola, O Zeps, N Grimmond, S Buckland, M Khasraw, M Sulman, EP Muscat, AM Stead, L https://orcid.org/0000-0002-9550-4150 The GLASS Consortium
Copyright, Publisher and Additional Information:	© The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords:	characterization; evolution; glioma; sequencing; subtypes
Dates:	Accepted: 2 February 2018 Published (online): 8 February 2018 Published: July 2018
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Brain Tumour Research (Leeds)
Funding Information:	Funder Grant number Leeds Teaching Hospitals Charitable Foundation 9R11/14-11
Depositing User:	Symplectic Publications
Date Deposited:	09 Apr 2018 11:45
Last Modified:	25 Jun 2023 21:18
Status:	Published
Publisher:	Oxford University Press
Identification Number:	10.1093/neuonc/noy020
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:129363

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Glioma Through the Looking GLASS: Molecular Evolution of Diffuse Gliomas and the Glioma Longitudinal AnalySiS Consortium

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