Hienola, A, Tumova, S orcid.org/0000-0003-2044-4998, Kulesskiy, E et al. (1 more author) (2006) N-syndecan deficiency impairs neural migration in brain. The Journal of Cell Biology, 174 (4). pp. 569-580. ISSN 0021-9525
Abstract
N-syndecan (syndecan-3) is a transmembrane proteoglycan that is abundantly expressed in the major axonal pathways and in the migratory routes of the developing brain. When ligated by heparin-binding (HB) growth-associated molecule (GAM; pleiotrophin), N-syndecan mediates cortactin–Src kinase-dependent neurite outgrowth. However, the functional role of N-syndecan in brain development remains unexplored. In this study, we show that N-syndecan deficiency perturbs the laminar structure of the cerebral cortex as a result of impaired radial migration. In addition, neural migration in the rostral migratory stream is impaired in the N-syndecan–null mice. We suggest that the migration defect depends on impaired HB-GAM–induced Src kinase activation and haptotactic migration. Furthermore, we show that N-syndecan interacts with EGF receptor (EGFR) at the plasma membrane and is required in EGFR-induced neuronal migration.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Animals; Carrier Proteins; Cell Differentiation; Cell Line; Cell Membrane; Cell Movement; Cell Proliferation; Cerebral Cortex; Cytokines; Fluorescence Resonance Energy Transfer; Membrane Glycoproteins; Mice; Mice, Knockout; Neurites; Neurons; Organ Culture Techniques; Proteoglycans; Receptor, Epidermal Growth Factor; Stem Cells; Syndecan-3; src-Family Kinases |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 19 Sep 2019 15:36 |
Last Modified: | 19 Sep 2019 15:36 |
Status: | Published |
Publisher: | Rockefeller University Press |
Identification Number: | 10.1083/jcb.200602043 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:128848 |