Brownlie, RJ, Zamoyska, R and Salmond, RJ orcid.org/0000-0002-1807-1056 (2018) Regulation of autoimmune and anti‐tumour T‐cell responses by PTPN22. Immunology, 154 (3). pp. 377-382. ISSN 0019-2805
Abstract
A number of polymorphisms in immune‐regulatory genes have been identified as risk factors for the development of autoimmune disease. PTPN22 (that encodes a tyrosine phosphatase) has been associated with the development of several autoimmune diseases, including type 1 diabetes, rheumatoid arthritis and systemic lupus erythematosus. PTPN22 regulates the activity and effector functions of multiple important immune cell types, including lymphocytes, granulocytes and myeloid cells. In this review, we describe the role of PTPN22 in regulating T‐cell activation and effector responses. We discuss progress in our understanding of the impact of PTPN22 in autoimmune disease in humans and mouse models, as well as recent evidence suggesting that genetic manipulation of PTPN22 expression might enhance the efficacy of anti‐tumour T‐cell responses.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Brownlie, R. J., Zamoyska, R. and Salmond, R. J. (2018), Regulation of autoimmune and anti‐tumour T‐cell responses by PTPN22. Immunology, 154: 377-382. doi:10.1111/imm.12919, which has been published in final form at https://doi.org/10.1111/imm.12919. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | autoimmunity; signal transduction; T‐cell; tumour immunology |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) |
Funding Information: | Funder Grant number Cancer Research UK C55663/A23269 |
Depositing User: | Symplectic Publications |
Date Deposited: | 21 Mar 2018 15:26 |
Last Modified: | 07 Mar 2019 01:39 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/imm.12919 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:128738 |