De Marco, M. and Venneri, A. (2018) Brain morphometry: Alzheimer’s disease. In: Spalletta, G., Piras, F. and Gili , T., (eds.) Brain Morphometry. Neuromethods (136). Springer , pp. 217-240. ISBN 9781493976454
Abstract
Brains suffering from Alzheimer’s disease show pronounced morphological modifications, with ample volumetric reduction of neural tissue. While particularly visible during the most severe disease stages, these changes are more subtle at the prodromal stage, which is the moment when a clinical diagnosis should be ideally reached. A large body of research has tried to disentangle the nature of such modifications, modeling the regional anatomical variability observed at various disease stages in samples and cohorts, implementing a number of different methodological avenues. The result is a complex picture in which brain morphology is not exclusively affected by disease processes, but is also under the influence of a large series of additional variables, which all contribute to the resulting phenotype via a tight network of multiple biological mechanisms. As a consequence, the study of morphological changes in AD highlights a sensible lack of clinical specificity. Despite these limitations, however, a large body of publications has highlighted the importance of brain morphology for the characterization of different phenotypic expressions of this disease and for the quantification of treatment effects.
Metadata
Item Type: | Book Section |
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Authors/Creators: |
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Editors: |
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Copyright, Publisher and Additional Information: | © Springer Science+Business Media, LLC 2018 |
Keywords: | Gray matter; Cerebral cortex; Treatment effects; Cognitive functions; Clinical diagnosis; Mild cognitive impairment; T1-weighted imaging; Structural MRI; Disease trait |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Neuroscience (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 19 Mar 2018 16:05 |
Last Modified: | 19 Mar 2018 16:05 |
Published Version: | https://doi.org/10.1007/978-1-4939-7647-8_14 |
Status: | Published |
Publisher: | Springer |
Series Name: | Neuromethods |
Refereed: | Yes |
Identification Number: | 10.1007/978-1-4939-7647-8_14 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:128694 |