Deisenhofer, A.K., Delgadillo, J. orcid.org/0000-0001-5349-230X, Rubel, J. et al. (4 more authors) (2018) Individual treatment selection for patients with posttraumatic stress disorder. Depression and Anxiety, 35 (6). pp. 541-550. ISSN 1091-4269
Abstract
Background: Trauma focused cognitive behavioral therapy (Tf-CBT) and eye movement desensitization and reprocessing (EMDR) are two highly effective treatment options for post-traumatic stress disorder (PTSD). Yet, on an individual level, PTSD patients vary substantially in treatment response. The aim of the paper is to test the application of a treatment selection method based on a personalized advantage index (PAI). Method: The study used clinical data for patients accessing treatment for PTSD in a primary care mental health service in the north of England. PTSD patients received either EMDR (N = 75) or Tf-CBT (N = 242). The Patient Health Questionnaire (PHQ-9) was used as an outcome measure for depressive symptoms associated with PTSD. Variables predicting differential treatment response were identified using an automated variable selection approach (genetic algorithm) and afterwards included in regression models, allowing the calculation of each patient’s personalized advantage index (PAI). Results: Age, employment status, gender and functional impairment were identified as relevant variables for Tf-CBT. For EMDR, baseline depressive symptoms as well as prescribed antidepressant medication were selected as predictor variables. Fifty-six percent of the patients (n = 125) had a PAI equal or higher than one standard deviation. From those patients, 62 (50%) did not receive their model-predicted treatment and could have benefited from a treatment assignment based on the PAI. Conclusions: Using a PAI-based algorithm has the potential to improve clinical decision-making and to enhance individual patient outcomes, although further replication is necessary before such an approach can be implemented in prospective studies.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Wiley Periodicals, Inc. This is an author produced version of a paper subsequently published in Depression and Anxiety. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | automated variable selection; eye movement desensitization and reprocessing; personalized advantage index; personalized medicine; post‐traumatic stress disorder; trauma focused cognitive behavioral therapy |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 15 Mar 2018 14:35 |
Last Modified: | 11 Nov 2020 08:58 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/da.22755 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:128568 |